Postdoctoral Scholar

Medical University of South Carolina

Charleston, SC

Job posting number: #7205749

Posted: January 9, 2024

Salary / Pay Rate: NIH scale

Application Deadline: Open Until Filled

Job Description

Seeking highly motivated individuals to work in the area of cellular signaling related to cancer development and progression. Candidates must have experience in molecular biology, biochemistry, and cell biology. Research in the laboratory is focused on two major areas: 1. Inhibition of RAS signaling and transformation; and 2. Role of the intersectin (ITSN) scaffold protein in oncogenic signaling. We have identified vulnerabilities in oncogenic RAS using novel biologics and are using these powerful tools to develop new therapeutic strategies to inhibit RAS-driven cancers (Khan et al Cell Reports,; Whaby et al JBC, doi: 10.1016/j.jbc.2022.102661; Spencer-Smith et al, Nat Chem Biol., doi: 10.1038/nchembio.2231; Khan et al Oncogene doi: 10.1038/s41388-018-0636-y; Khan et al, Small GTPases, dox: 10.1080/21541248.2021.1906621). Current studies are examining the importance of RAS dimerization/nanoclustering in activation of RAS effector pathways, using novel affinity reagents to probe isoform-specific differences in RAS signaling, and identification of small molecule RAS inhibitors. In addition, we are studying the role of the ITSN scaffold protein in regulating cellular signaling pathways involved in human cancers, in particular neuroblastoma (Herrero-Garcia, E. and O’Bryan,J.P., BBA-MRC, doi: 10.1016/j.bbamcr.2016.10.005; Russo, A. and O’Bryan, J.P., Oncogene, doi: 10.1038/onc.2011.643; Harris, J., et. al. J. Pediatr. Hematol. Oncol. doi: 10.1097/MPH.0000000000000931). Current projects center on ITSN’s role in regulating RAS family GTPases, lipid kinases, ubiquitin ligases, protein trafficking pathways, and the importance of these ITSN-regulated pathways in human disease, particularly cancer.

Applicants must have a Ph.D. or M.D. degree and be eligible for employment in the U.S. Preference will be given to candidates with strong skills in molecular biology, biochemistry, tissue culture, and animal work. These are non tenure-track positions, with renewal dependent on successful progress and continued funding. Start date is negotiable although preference will be given to candidates that can begin immediately. Salary range is commensurate with experience according to NIH scale for postdocs. Position is a benefit eligible position. For fullest consideration send electronic file containing statement of research interest and experience, curriculum vitae, and names of three references to: Dr. John P. O’Bryan, email: [email protected]. Applicants should also apply online at:

Founded in 1824, The Medical University of South Carolina (MUSC) is now the core of the state’s largest medical complex and one of its largest employers with over 11,000 employees. Our research laboratory space exceeds 1 Million square feet. Extramural research funding awards to MUSC in 2017 exceeded $250 million. In addition, MUSC was named on Forbes first-ever list of America’s Best Employers for Diversity.

The Hollings Cancer Center (HCC) is the only NCI-Designated Cancer Center in South Carolina. Currently, HCC researchers hold approximately $45 Million in annual extramural cancer research funding with $23 Million originating from the NCI.

MUSC is located in historic Charleston, South Carolina. The weather is beautiful year-round, with temperatures rarely dropping below freezing during winter. There are several beaches within minutes of the city and the mountains are only three hours away. In addition to these amenities, the art, history, food, and festivals make Charleston an outstanding place to live.

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.

Medical University of South Carolina participates in the federal E-Verify program to confirm the identity and employment authorization of all newly hired employees. For further information about the E-Verify program, please click here:

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Job posting number:#7205749
Application Deadline:Open Until Filled
Employer Location:Medical University of South Carolina
Charleston,South Carolina
United States
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