Postdoctoral Fellow in Chemical Biology (Cancer Drug Discovery)

H. Lee Moffitt Cancer Center

Tampa, FL

Job posting number: #7121733 (Ref:62258)

Posted: January 21, 2023

Application Deadline: Open Until Filled

Job Description

At Moffitt Cancer Center, we come face-to-face with cancer every day, but we also see courage. And it inspires us to be the safest and best place for cancer care – to bring greater hope to every patient we serve. It’s why we’ve been continually named One of the Top Places to Work in the Tampa Bay Area. As the only National Cancer Institute-designated Comprehensive Cancer Center based in Florida, Moffitt employs some of the best and brightest minds from around the world. Moffitt is the leading cancer hospital in both Florida and the Southeast and has been nationally ranked by U.S. News & World Report since 1999. Because working at Moffitt is both a career and a mission: to contribute to the prevention and cure of cancer. Join a dedicated, diverse and inclusive team of over 7,000 to be a part of the Courageous future we envision.


Postdoctoral Fellow in Chemical Biology (Cancer Drug Discovery)


The Rix lab at the H. Lee Moffitt Cancer Center & Research Institute (Tampa, FL) is seeking a highly motivated and collaborative chemical biologist and/or molecular biologist to join a comprehensive drug discovery program to identify and validate novel cancer-relevant targets that serve as starting points for collaborative drug discovery efforts.


We are conducting highly interdisciplinary research focused on target identification, functional target validation and systems biology approaches towards elucidating cancer cell vulnerabilities and drug mechanisms of action using cellular compound screening, proteomics, molecular biology, biochemistry and bioinformatics. For further information on our laboratory and research program, please visit –



Position Highlights:

  • The successful candidate will be involved in screening fragment-like small molecules in cancer cells, performing mass spectrometry-based chemical proteomics to identify target proteins and conducting biochemical and cellular validation assays of new cancer targets.
  • The position will allow the candidate to develop valuable new skills and experience in chemical biology, proteomics and drug discovery that include but are not limited to:
    • Designing, performing and analyzing of cell-based compound screens
    • Designing, performing and analyzing of chemical and other functional proteomics experiments
    • Candidate compound and target selection
    • Analysis of in vitro and cellular activity of compounds
    • Access to multiple high-quality core facilities equipped with state-of-the-art instrumentation


The Ideal Candidate:

  • The candidate must have strong experience in mammalian cell culture, immunoblotting, immunofluorescence, immunoprecipitation, molecular cloning, RNA interference, CRISPR/Cas9 gene editing and statistics.
  • Experience with mass spectrometry-based proteomics is a plus.
  • Experience with “click” chemistry is a plus.
  • Experience in developing/adapting functional biochemical assays is a plus.
  • Excellent analytical skills and the ability to interpret complex information and data.
  • Excellent oral and written communication skills are required.
  • Ability to efficiently operate in a multidisciplinary and team-oriented research environment and closely communicate and coordinate efforts with project chemists and staff in proteomics and bioinformatics core facilities.



  • The duties will include designing, conducting and analyzing cellular screening and chemical proteomics experiments
  • Perform cellular validation studies of targets and pathways using genetic and pharmacological tools.
  • Design, conduct and analyze biochemical assays for compound binding and functional modulation of target.
  • Contribute to the development of research techniques and methods in collaboration with other lab members.
  • Documentation of all experiments in electronic notebooks including written, publication- quality experimental procedures.
  • Present research outputs, including drafting academic publications or parts thereof, posters and oral presentations
  • Provide guidance, as required, to support any graduate or undergraduate students who may be assisting with the research.
  • Contribute to Center-wide drug discovery activities.


Credentials and Qualifications:

  • Applicant must have a Ph.D. in chemical biology, biochemistry or molecular biology with specific experience in mechanistic validation of targets and pathways. A pending doctoral degree may be considered with approval of the Principal Investigator.


How to Apply:

Interested applicants should send a single PDF file by email that includes:

  1. a cover letter outlining candidate’s motivations and suitability
  2. a summary of research accomplishments (4 pages maximum)
  3. current CV with recent publications and
  4. contact information for three references to Dr. Rix [email protected]

Mission To create a Moffitt culture of diversity, equity, and inclusion as we strive to contribute to the prevention and cure of cancer. Vision To advance and accelerate a culture of access, equity, and inclusion. Diversity is a priority at Moffitt and is meant "to promote a culture of diversity and inclusion as we contribute to the prevention and cure of cancer." The Enterprise Equity Department focuses its efforts on eliminating those obstacles to an individual’s ability to exist within their personal comfort zone at the cancer center. Everyone is important to meeting this priority. Addressing and responding to diversity and inclusion fosters an environment where mutual respect for diverse cultures, communication styles, languages, customs, beliefs, values, traditions, experiences and other ways in which we identify ourselves, is the expectation.

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