Postdoctoral Associate- Neuropharmacological Consequences of Brain Iron Insufficiency

Johns Hopkins University School of Medicine

Baltimore, MD

Job posting number: #7086381

Posted: September 30, 2021

Job Description

Robert and Sherrie Frankel Postdoctoral Fellowship in RLS Research
A postdoctoral associate position is available to study the pharmacological and neurochemical consequences of brain iron insufficiency in rodent models of Restless Legs Syndrome (RLS). The studies will be done in collaboration with Dr. Sergi Ferré at National Institute of Drug Abuse. We are currently implementing translational research utilizing the rodent iron-deficiency model of RLS to develop potentially new treatments for RLS. This research includes the consequences of brain iron insufficiency in the adenosinergic system, which we predicted and recently demonstrated it could have a significant clinical application. We will now use a combination of ex vivo neurochemical techniques (Western blotting, RNAscope) and a sophisticated in vivo approach to measure adenosine (fiberphotometry-microdialysis) in selected BXD RI mice strains, to study the contribution of complex genetics to brain iron homeostasis and its consequence on the adenosinergic system.
Applicants should have a Ph.D. and/or M.D. and be creative and highly motivated. A strong background in brain stereotaxic techniques in mice and basic neurochemical techniques is highly desirable.
Representative publications:
-Yepes G, Guitart X, Rea W, et al. Targeting hypersensitive corticostriatal terminals in restless legs syndrome. Ann Neurol. 2017;82:951-960.
-Ferré S, Quiroz C, Guitart X, et al. Pivotal Role of Adenosine Neurotransmission in Restless Legs Syndrome. Front Neurosci. 2017;11:722.
-Ferré S, García-Borreguero D, Allen RP, Earley CJ. New Insights into the Neurobiology of Restless Legs Syndrome. Neuroscientist. 2019;25:113-125.
-Garcia-Borreguero D, Garcia-Malo C, Granizo JJ, Ferré S. A Randomized, Placebo-Controlled Crossover Study with Dipyridamole for Restless Legs Syndrome. Mov Disord. 2021;10.1002/mds.28668.

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