Research Technician III - Human Genome Sequencing Center - Clia Lab

Baylor College of Medicine

Houston, TX

Job posting number: #7079610 (Ref:7315-en_US)

Posted: June 9, 2021

Application Deadline: Open Until Filled

Job Description


The BCM-HGSC was founded in 1996 under the leadership of Dr. Richard Gibbs and is a world leader in genomics. The fundamental interests of the BCM-HGSC are in advancing biology and genetics by improved genome technologies. As one of the large-scale sequencing centers funded by the National Institutes of Health, the BCM-HGSC provides a unique opportunity to work on the cutting edge of genomic science in a state of the art institution.


The Human Genome Sequencing Center (HGSC) at Baylor College of Medicine is seeking to recruit a Research Technician III to work in its CLIA laboratory conducting next-generation sequencing assays. 


Qualified candidates should have molecular biology experience and good organizational skills. The position will involve one or more of the following duties: DNA and RNA QC, Real-time PCR, and library construction. Proficiency in MS Word and MS Excel is necessary. Qualified candidates should be good at multi-tasking, problem-solving, and have strong communication skills. The candidate should be able to work well in a team environment.

Job Duties

•    Perform pipeline production in CL for NGS library preparation with liquid handling systems
•    Conduct laboratory routine instrument maintenance, reagent testing and consumable tracking to keep production going without interruption
•    Participate in lab compliance activities to comply CAP, CLIA, HIPPA and all relevant Federal, State and local regulations
•    Initiate Automation library report for QC metrics and reagent lot records. 
•    Array and prepare samples for Covaris application and QC documentation.
•    Prepare Illumina paired end library on Biomek FXP, which also includes Agilent QC, Alphaview QC, pooling and Ampure bead cleanup. 
•    Prepare  Illumina Adaptor Trays, Binding buffer, and aliquoting reagents necessary for library prep.
•    Provide detailed and legible library documentation associated with results, maintenance records, and quality control.
•    Order reagents and labware needed for automated preparation of Library.
•    Perform monthly inventory of automation pipeline reagents
•    Routine maintenance of automated equipment.
•    Assist and train staff in basic molecular biology processes for library preparation. 
•    Assist team lead in updating management with HGSC-CLIA robotic updates. 
•    Participate in library troubleshooting as assigned. 
•    Validate Robotic scripts for library preparation and report results to management.
•    Assist Robotics Team in Biomek script development. Work with Robotics Team to implement Biomek Methods for automated library preparation.
•    Stay current with Next Generation Sequencing Literature.

Minimum Qualifications

  • Bachelor's degree in a Basic Science or related field. Four years of related experience may substitute for degree requirement.
  • One year of relevant experience.

Preferred Qualifications

  • Master's degree in a related field.





Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.



Baylor College of Medicine fosters diversity among its students, trainees, faculty and staff as a prerequisite to accomplishing our institutional mission, and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. - Diversity, respect, and inclusiveness create an environment that is conducive to academic excellence, and strengthens our institution by increasing talent, encouraging creativity, and ensuring a broader perspective. - Diversity helps position Baylor to reduce disparities in health and healthcare access and to better address the needs of the community we serve. - Baylor is committed to recruiting and retaining outstanding students, trainees, faculty and staff from diverse backgrounds by providing a welcoming, supportive learning environment for all members of the Baylor community.

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