The lab of Dr. St-Pierre (stpierrelab.com) develops and applies new tools for imaging the brain in animal models with cellular and subcellular resolution. We are particularly interested in genetically encoded voltage indicators (GEVIs) which are biosensors based on fluorescent proteins that reports voltage as changes in brightness. GEVI therefore promise to enable non-invasive monitoring of neural electrical activity by imaging rather than by traditional electrophysiological methods. These indicators have already been applied in Drosophila and in rodent brain slices but need further improvement to be of broad utility in mammalian in vivo models.
We are seeking a new energetic team member to lead our efforts to characterize and apply this exciting new technology in vitro and in vivo. Detailed characterization of these tools requires electrophysiology, hence this current position. An ideal candidate is someone who has experience with electrophysiology in dissociated neurons and brain slices. This position provides exciting opportunities for candidates to develop new skills in two-photon voltage imaging, protein engineering, and synthetic biology.
Performs complex research of an advanced nature under the general direction of the Principal Investigator. Typically requires a high-level of skills and expertise in the area of research specialty.
Conducts research projects, both independently and with others.
Purchases, sets up and maintains equipment necessary to conduct research.
Teaches techniques, procedures, and experimental design to other members of the lab.
Communicates research results during our group meetings, and in local/national/international research meetings and conferences.
Master's degree in Basic Science or a related field. Experience in lieu of degree will not be accepted.
Three years of relevant experience, typically as a Research Assistant, Research Technician or Postdoctoral Fellow/Associate.
Ph.D. or 4 years of relevant laboratory or industry experience.
Preferred Technical Skills:
Ability to perform electrophysiology in dissociated neurons and in brain slices.
Ability to dissect rat cortical, hippocampal neurons, or both.
Ability to maintain an electrophysiology rig.
Ability to express transgenes in neurons of brain slices using viruses and/or in utero electroporation.
Experience with imaging neural activity (e.g. voltage or calcium) in brain slices or in vivo, using 1P and/or 2P imaging.
Ability to code using Matlab, Python, or other languages.
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