Research Associate - Electrophysiological - Neuroscience (90002091)

Baylor College of Medicine

Houston, TX

Job posting number: #7079525 (Ref:7203-en_US)

Posted: June 7, 2021

Application Deadline: Open Until Filled

Job Description

Summary

The lab of Dr. St-Pierre (stpierrelab.com) develops and applies new tools for imaging the brain in animal models with cellular and subcellular resolution. We are particularly interested in genetically encoded voltage indicators (GEVIs) which are biosensors based on fluorescent proteins that reports voltage as changes in brightness. GEVI therefore promise to enable non-invasive monitoring of neural electrical activity by imaging rather than by traditional electrophysiological methods. These indicators have already been applied in Drosophila and in rodent brain slices but need further improvement to be of broad utility in mammalian in vivo models.

We are seeking a new energetic team member to lead our efforts to characterize and apply this exciting new technology in vitro and in vivo. Detailed characterization of these tools requires electrophysiology, hence this current position. An ideal candidate is someone who has experience with electrophysiology in dissociated neurons and brain slices. This position provides exciting opportunities for candidates to develop new skills in two-photon voltage imaging, protein engineering, and synthetic biology.

Job Purpose

Performs complex research of an advanced nature under the general direction of the Principal Investigator.  Typically requires a high-level of skills and expertise in the area of research specialty.

Job Duties

  • Conducts research projects, both independently and with others. 
  • Purchases, sets up and maintains equipment necessary to conduct research. 
  • Teaches techniques, procedures, and experimental design to other members of the lab.  
  • Communicates research results during our group meetings, and in local/national/international research meetings and conferences.

Minimum Qualifications

  • Master's degree in Basic Science or a related field.  Experience in lieu of degree will not be accepted.
  • Three years of relevant experience, typically as a Research Assistant, Research Technician or Postdoctoral Fellow/Associate.

Preferred Qualifications

  • Ph.D. or 4 years of relevant laboratory or industry experience. 

Preferred Technical Skills:

  • Ability to perform electrophysiology in dissociated neurons and in brain slices.
  • Ability to dissect rat cortical, hippocampal neurons, or both.
  • Ability to maintain an electrophysiology rig.

Desirable Skills:

  • Ability to express transgenes in neurons of brain slices using viruses and/or in utero electroporation.
  • Experience with imaging neural activity (e.g. voltage or calcium) in brain slices or in vivo, using 1P and/or 2P imaging.
  • Ability to code using Matlab, Python, or other languages.

 

 

 

 

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

 7203

CA 



Baylor College of Medicine fosters diversity among its students, trainees, faculty and staff as a prerequisite to accomplishing our institutional mission, and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. - Diversity, respect, and inclusiveness create an environment that is conducive to academic excellence, and strengthens our institution by increasing talent, encouraging creativity, and ensuring a broader perspective. - Diversity helps position Baylor to reduce disparities in health and healthcare access and to better address the needs of the community we serve. - Baylor is committed to recruiting and retaining outstanding students, trainees, faculty and staff from diverse backgrounds by providing a welcoming, supportive learning environment for all members of the Baylor community.


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