Research Assistant I Lab

Harvard Medical School

Boston, MA

Job posting number: #7079050

Posted: May 26, 2021

Application Deadline: Open Until Filled

Job Description

Job-Specific Responsibilities

We are looking for an independent and motivated research associate to join a group led by Adam Granger under the supervision of Bernardo Sabatini at Harvard Medical School. Our research is broadly interested in the molecular, cellular, and circuit mechanisms that underly neurodegenerative and neuropsychiatric disease. We use a wide range of techniques including biochemistry, virology, electrophysiology, and advanced microscopy to study how cells and circuits in the brain operate in healthy conditions and during disease states. In particular, we are recruiting for a project that will study how microglial phagocytosis changes and contributes to neurodegeneration in Alzheimer’s disease.

Successful candidates will be independent, outgoing, flexible, self-motivated, and able to assimilate new information and execute quickly. You will have the opportunity to direct an independent research project while taking advantage of the diverse, welcoming, and exciting team of researchers at the Sabatini lab.

Duties of this position will include
Biochemical extraction, isolation, and analysis of mouse brain tissue.
Mouse husbandry.
Tissue culture of heterologous and neuronal cells.
Processing of mouse brain tissue for anatomical and spatial transcriptomic analysis.
Basic molecular biology including plasmid construction, transfection, and expression screening.
Data and Imaging analysis.
Careful record keeping and documentation of experimental protocols and results.
Attend and present at team meetings to share results and plan experiments.
Oversee lab stocks to help manage the ordering of reagents and supplies.
Help with the adherence to lab safety and animal care use.
Other duties as needed

Basic Qualifications

College background and at least one year of related lab experience.

Additional Qualifications and Skills

Excellent organizational and communication skills are required. BS. Or M.S. with prior experience in a wet lab environment - Experience with biochemistry including immunoprecipitation, western blots, and proteomics highly desirable. Experience or willingness to work with mice, manage a mouse colony, and perform survival and non-survival procedures as necessary, a must. Candidates should be communicative with excellent interpersonal skills, attentive to detail, organized, and thoughtful about the protocols and techniques being executed. Creativity, flexibility, and perseverance to troubleshoot and overcome inevitable experimental difficulties and changing experimental goals in light of new results. Must be able to schedule time and accomplish multiple experiments within a single day. Ideal candidates will have demonstrated experience with the ability to troubleshoot, problem-solve and be capable of carefully following standard operating procedures and accurately making notations when deviations occur. This position is for a 12-month term with the option to renew, we’d ideally prefer a candidate who is looking to stay for 2 years.

Additional Information

This is a 12-month term appointment with the possibility of renewal contingent on funding.

Offer contingent upon successful completion of a pre-placement medical evaluation.

Harvard Medical School strives to cultivate an environment that promotes inclusiveness and collaboration among students, faculty and staff and to create new avenues for discussion that will advance our shared mission to improve the health of people throughout the world.

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