Research Assistant II - DNA Nanotechnology for Microscopy and Sequencing

Harvard Medical School

Boston, MA

Job posting number: #7078655

Posted: May 18, 2021

Application Deadline: Open Until Filled

Job Description

Job Summary

About us:
The Wyss Institute’s mission is to transform healthcare and the environment by emulating the way nature builds. We harness the freedom of academia and the focus of industry in order to translate revolutionary technologies into commercial products and solutions. At the Wyss Institute, faculty from premier academic and clinical institutions, collaborate with staff scientists, postdocs, graduate students, industry experts, business development leaders, and entrepreneurs across disciplines to invent and de- risk new technologies that don’t just succeed at making it to the market – they disrupt it. We support research that universities, companies, and venture capital firms don’t fund because they view it as too risky. We prefer to use the word “challenging,” and we love challenges. For more information, visit:

About You:
You are a collaborative, impact-focused problem solver who wants to be part of a dynamic team dedicated to creating and commercializing novel approaches to global challenges in healthcare and sustainability. You want the freedom to explore, to push the boundaries of what is possible, and to use your ambition to tackle challenging projects in a fast-paced, industry-focused environment without a lot of administrative hurdles. You enjoy working with diverse groups of people and leveraging your expertise to create innovations that can change the world.

About the role:
We are looking for a talented, enthusiastic Research Assistant II to join Peng Yin’s lab. The lab specializes in developing and applying DNA-based technology, including the application of DNA probes to transform biomolecular imaging and understand nano-scale organization. Recent techniques developed there include super- resolution and highly multiplexed DNA-based optical imaging methods, as well as complementary methods of recording macromolecular features in synthetic DNA for sequencing readout.

In this role, you may work on a variety of these and related imaging- and sequencing-based projects, applying molecular biology protocols to construct, amplify, conjugate, or assemble DNA components and in turn apply them to recording or imaging applications in vitro (e.g., proteins in solution) or in vivo (e.g., live or fixed cells). You will also have an opportunity to use specialized laboratory equipment, which may include advanced optical microscopes (e.g., fluorescence, TIRF, or confocal), Next Generation Sequencers, and a variety of cell and molecular biology equipment.

This role will also give you access to a range of professional development and collaboration opportunities at the Wyss. You will be able to take advantage of relevant training and will interact with students, postdocs and faculty.

Job-Specific Responsibilities

What you’ll do:

With supervision from senior lab members, follow existing protocols or help develop new protocols
Manage equipment, reagents, and experimental data
Contribute towards the presentation of data at external and internal meetings

Basic Qualifications

What you’ll need:

College background or equivalent work experience in Biology, Immunology, Chemistry, Molecular Biology, Engineering or related field.
A minimum of one year of directly related work experience. Higher education may count toward years of experience.

Additional Qualifications and Skills

Desirable Skills:

Bachelor’s degree preferred
2+ years of research experience, preferably including experience with cell culture, molecular biology protocols (e.g., PCR), biochemistry protocols (e.g., antibody conjugations, purifications), tissue processing, in situ staining protocols (IF, IHC, FISH), fluorescence microscopy, and/or image analysis is preferred
Good laboratory practices, attention to detail
Experience in planning experiments and adjusting protocols, organizing data, and maintenance of lab notebook
Competence in time management and working independently to achieve specific research milestones
Effective communication (oral and written) skills and management of interactions with multiple lab members
Basic computer skills

Harvard Medical School strives to cultivate an environment that promotes inclusiveness and collaboration among students, faculty and staff and to create new avenues for discussion that will advance our shared mission to improve the health of people throughout the world.

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