Bioinformatics Analyst I/II

The Jackson Laboratory for Genomic Medicine

Farmington, CT

Job posting number: #7072378 (Ref:JAX28127)

Posted: November 20, 2020

Application Deadline: Open Until Filled

Job Description


The Stitzel Lab seeks a highly motivated, innovative, driven, and independent Bioinformatics Analyst who will perform processing, analysis, and visualization of the vast next generation sequencing data generated by ‘omics experiments such as ATAC-seq, RNA-seq, and single cell sequencing and collaborate, integrate, and communicate with the bench and other computational scientists generating and analyzing these data.


Their overarching goal is to understand the genomic and cellular underpinnings of islet (dys)function and diabetes. They employ innovative (epi)genomic profiling and single cell genomic technologies, human cellular and mouse models, and CRISPR/Cas9 (epi)genome editing platforms to identify key genes and pathways controlling human islet cell identity and function and to understand how diabetes-associated DNA sequence variants and environmental stimuli/stressors alter these programs to contribute to islet failure in diabetes.


This is a highly collaborative and integrated environment with multiple projects. Dr. Stitzel will supervise this position directly. Thus, he will determine assignment and prioritization of projects, as well as assessment of progress on projects, in direct consultation with this computational scientist.


  • Processing, visualization, and analysis of epigenome (ATAC-seq), transcriptome (RNA-seq), and single cell (scRNA-seq, snATAC-seq) next generation sequencing (NGS) data
  • Implementing and running pipelines and software packages for differential epigenome/transcriptome (e.g., EdgeR, limma), single cell (e.g., Seurat, scanpy), and allelic and human-mouse comparative analyses
  • Contribute to the writing of research manuscripts
  • Arrange and deposit NGS data to appropriate public repositories (e.g., dbGaP, GEO, etc.) upon manuscript acceptance/publication
  • Implementing and/or developing publically-accessible databases to share Stitzel Lab and related JAX Cube data and results with the islet biology and biomedical research communities


  • Level I requires BS or MS degree in bioinformatics, computational biology, or relevent biological sciences degree. Incumbents who have not achieved Masters degree may compensate for lack of a degree with at least 5 years of professional bioinformatics work experience. Works under close supervision.
  •  Level II requires MS or PhD degree in bioinformatics, computational biology, or relevent biological sciences degree. Incumbents who have not achieved a Ph.D, may compensate with a Masters degree and at least 5 years of professional work experience in bioinformatics. Works with limited supervision for tasks performed.


Desired Skills and Experience:

  • Solid knowledge of scripting languages (Perl, Python, or R), and Unix OS are strictly required
  • Familiarity with Bioconductor and/or Bioconda bioinformatics software libraries
  • Experience in applying/developing computational algorithms and systems to support genetics and genomics research
  • Experience with popular NGS analysis software (BWA, bowtie, RSEM, CellRanger, etc.)

About Us

The Jackson Laboratory (JAX) is an independent, nonprofit biomedical research institution with more than 2,300 employees. Headquartered in Bar Harbor, Maine, it has a National Cancer Institute-designated Cancer Center in Augusta, Maine, a genomic medicine institute in Farmington, Connecticut, and facilities in Ellsworth, Maine, Sacramento, California, and Shanghai, China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

JAX Genomic Medicine is transforming medicine by improving patient care, lowering costs, and increasing life span and health span. JAX Genomic Medicine’s research focuses on the complex genetic causes of disease and on the development of genomic solutions tailored to each person's unique genetic makeup.


JAX Genomic Medicine sits on a 17-acre site on the campus of the University of Connecticut Health Center. The 183,500-square-foot facility opened in the fall of 2014. Now, it houses over 300 biomedical researchers, technicians, and support staff in state-of-the-art computing facilities and laboratories.


In Connecticut, JAX resides in the scenic town of Farmington, in the state’s capitol region. The Hartford region, which offers some of the best public schools in the country, is made up of both bigger cities and smaller, charming historic New England towns.  JAX Genomic Medicine is also geographically located within 2 hours of Boston and New York and is close to multiple transportation systems, including bus lines, highways, railroads and international airports.


JAX employees work in a collaborative, value-driven, and team-based environment where the focus is on advancing science and improving patients’ lives. Researchers apply genetics to increase the understanding of human disease and advance treatments and cures for cancer, neurological and immune disorders, diabetes, aging, and heart disease. JAX was voted among the top 15 “Best Places to Work in Academia” in the United States in a poll conducted by The Scientist magazine!


Our Values:

INTEGRITY - Courage and commitment to do what is right

PEOPLE - Inspiring our people to enhance the health of all

ONE TEAM - Unified by our promise to transform medicine and science

EXCELLENCE - Achieving world-class results

INNOVATION - Leading with discovery and creative solutions

STEWARDSHIP - Caring for and enhancing the resources entrusted to us


What do we have to offer?

JAX offers a dynamic and supportive work environment, competitive salaries, and a comprehensive benefits package, including a medical plan, outstanding retirement plan, generous paid time off, and tuition reimbursement including an MBA program. Our campus offers a fitness center with an award-winning wellness program and an onsite full service cafeteria.

Most importantly, every position contributes to JAX’s mission of discovering precise genomic solutions for human disease and empowering the global biomedical community in our shared quest to improve human health.


Employment will require successful completion of references, background check, and an appropriate non-compete agreement.

The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.

Learn more about career opportunities at JAX:


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More Info

Job posting number:#7072378 (Ref:JAX28127)
Application Deadline:Open Until Filled
Employer Location:The Jackson Laboratory for Genomic Medicine
United States
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