Postdoctoral Fellow in Neuromuscular Disease

Johns Hopkins School of Medicine

Baltimore, MD

Job posting number: #7063399

Posted: February 6, 2020

Job Description

Immune Response in Neuromuscular Degeneration

The Lloyd lab at Johns Hopkins is seeking a postdoctoral fellow with expertise in Immunology, Muscle Biology, and/or Mouse Models of neuromuscular disease to study the interaction between the immune system and regenerating muscle in a humanized mouse model. Increasing evidence suggests that the adaptive and innate immune system play critical roles in the pathogenesis of neuromuscular degenerative diseases including “TDP-43 proteinopathies” like Inclusion Body Myositis (IBM) and Amyotrophic Lateral Sclerosis (ALS).

The Johns Hopkins Myositis Center routinely performs xenotransplantation of human muscle biopsy specimens into immunodeficient mice to create personalized animal models of myositis. We are using state-of-the-art multiomics approaches such as single-cell RNA sequencing to understand the interaction between the human immune system and muscle within a mouse host. We are also partnering with industry to use these models to test the efficacy of novel biologics as potential therapies for these debilitating degenerative diseases.

The Lloyd laboratory (https://lloydlab.jhmi.edu/Home) uses a combination of genetic, molecular, cellular, physiologic, and imaging approaches in Drosophila, mouse, and iPS models in addition to human tissue to study the cell biology of degenerative diseases affecting the neuromuscular system.

Recent relevant publications include: Britson KA et al (2019) JoVE Sep 16;151; Vogler et al (2019) Nature 563:508; Zhang K et al (2018) Cell 173:958. Highly motivated and energetic candidates with a strong publication record are encouraged to apply. Interested applicants should send curriculum vitae to tlloyd4@jhmi.edu.




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