Research Associate

University of Virginia

Charlottesville, VA

Job posting number: #7062563 (Ref:R0012255)

Posted: December 3, 2019

Application Deadline: Open Until Filled

Job Description

The Bushweller Laboratory in the Department of Molecular Physiology and Biological Physics at the University of Virginia seeks a Research Associate. The successful candidate will perform research in structural biology of protein-RNA interactions and various small molecule screening efforts targeting transcription factors. The laboratory is interested in understanding the role of RNA binding in regulating critical regulators of blood cell development, hematopoiesis, and leukemia. This person will also contribute to efforts to develop small molecule inhibitors of transcription factors that are targets in leukemia. The project requires a combination of techniques from molecular biology, protein purification, NMR spectroscopy, protein crystallography, screening, and biochemistry.

More information about the lab can be found on our website:

The structure of protein-RNA complexes will be determined using either NMR spectroscopy or X-ray crystallography. This person will also be carrying out small molecule screens with target transcription factors using fluorescence based methods and characterizing the ligand-protein interactions using NMR spectroscopy and X-ray crystallography. This person will also be responsible for training graduate and undergraduate students. The successful candidate will have access to state-of-the-art crystallography and NMR-spectroscopy facilities.

The highly motivated candidate must have a Ph.D. in Biochemistry, Molecular Biology, Biophysics, or a related field and must have at least one publication in a peer-reviewed journal, extensive experience in cloning and protein expression and purification, and should have knowledge of protein crystallography and NMR spectroscopy. Significant experience in NMR spectroscopy applications to proteins is preferred but not required. The ability to work independently yet to interact well with a diverse group of scientists and students is essential.

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